A severe ant infestation that does not respond to basic treatments requires a coordinated, multi-pronged response that targets the colony and stops reinfestation quickly.

Start by identifying the ant species because behavior guides strategy; take clear photos and note where trails and nests are located. Deep cleaning is essential so remove all food sources by storing pantry items in airtight containers, wiping surfaces with hot soapy water, and removing standing water and pet food overnight. Use bait stations with slow-acting boric acid or sugar-based baits for sugar-loving species and protein or grease-based baits for meat-preferring species, placing them along trails and near entry points but out of reach of children and pets. Apply perimeter granules around the foundation and use nonrepellent residual sprays in wall voids and baseboards for long-lasting protection, following product label directions for safety and effectiveness. Locate and seal entry points by tracing trails back to gaps around windows, doors, pipes and foundation cracks, using silicone caulk or expanding foam as appropriate to block access. If nests are outside near the structure, treat around the nest with targeted insecticidal dust and collapse or remove the nest area when safe to do so to prevent reestablishment.

Common mistakes include chasing visible ants with sprays only and not addressing the colony, which temporarily removes workers but leaves the queen intact so switch to baiting that reaches the colony. Another issue is using the wrong bait type for the species so observe whether ants prefer sweet or greasy foods and adjust bait formulation accordingly. A third concern is ignoring structural entry points, so after reducing activity, thoroughly inspect and seal cracks and gaps and maintain exterior cleanliness to prevent future invasions.

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